Chromatin Interaction Analysis by Paired-End Tag Sequencing (ChIA-PET)
ChIA-PET has been used to identify long-range interactions at promoters and enhancers at high resolution in various cell types and species
cite:Shen Y, Yue F, McCleary DF, et al. Nature 2012; 488:116–120.
Requires hundreds of million cells as starting materials because chromatin immunoprecipitation and proximity ligation are performed after chromatin shearing, which potentially leads to great disruption of protein/DNA complexes.