Enhancer
An enhancer is a distal regulatory DNA segment that enhances the transcription of a target gene by interacting with the target gene promoter.
Models
TODO Tracking
TODO Linking/chaining
TODO Short-rang looping
Bacteria, λ lambda
TODO Loop-tracking/linking
Greater than 2 Million enhancers for 20,000 genes
Enhancer-Promoter Interaction
Multiple enhancers can regulate one gene
EP Interaction [@Kim2018]
Enhancer Transcription
Backlinks
- Notes on Yao, Liang, Ozer, Leung, Lis, Yu, A comparison of experimental assays and analytical methods for genome-wide identification of active enhancers
- Single-cell epigenomics reveals mechanisms of human cortical development : (Ziffra_2021)
- Corsi_2015: A transparent window into biology: a primer on caenorhabditis elegans
- Malladi_2020: Total functional score of enhancer elements identifies lineage-specific enhancers that drive differentiation of pancreatic cells
- Sartorelli_2020: Enhancer RNAs are an important regulatory layer of the epigenome
- Visel_2009: Genomic Views of Distant-Acting Enhancers
- BIOL5420 - Molecular Biology
- BIOL6193 - Colloquium in Molecular and Cell Biology
- /cis/-regulatory elements
- Enhancer RNA (eRNA)