Minnoye_2021
Minnoye2021
Introduction
Nucleosome
~147 bp of DNA wrapped around an octamer of histones
Typically depleted at cis-regulatory elements (enhancers and promoters)
Cis-regulatory elements
Non-coding DNA regions involved in the regulation of expression of neighbouring genes. The regions contain binding sites for transcription factors.
Accessible chromatin
A permissive state of the chromatin in which nuclear macromolecules are able to physically access and interact with the DNA.